abstract::Silk fibroin (SF) is a natural polymeric biomaterial that is widely adopted for the preparation of drug delivery systems. Herein, we aimed to fabricate and characterize SF nanoparticles loaded with the selective estrogen receptor modulator; tamoxifen citrate (TC-SF-NPs) and to assess their in vitro efficacy against br...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1958106
更新日期:2021-12-01 00:00:00
abstract::Pharmacotherapy training for pediatric residents is an important part of their overall education. Limited data exist describing formal engagement of clinical pharmacists in residency training. The objective of this study was to evaluate a novel pharmacotherapy rotation for learner gains and program feasibility. We des...
journal_title:Medical education onlinepub_type: 杂志文章
doi:10.1080/10872981.2021.1955645
更新日期:2021-12-01 00:00:00
abstract::Colorimetric pH strips (MColorpHast™) are very convenient to use, but the decision of pH is based on an individual's color perception and is, therefore, subjective. We developed a pH calculation program for the image of coloring strips on CIE1976 (L*a*b* color space), which slightly underestimated human judgment as th...
journal_title:Animal science journal = Nihon chikusan Gakkaihopub_type: 杂志文章
doi:10.1111/asj.13602
更新日期:2021-12-01 00:00:00
abstract::Halal products are growing in consumer markets worldwide, and pork meat is classified as non-halal. Manufacturers of processed foods and products must ensure that their products follow Islamic dietary law because pork is prohibited for Muslims. Droplet digital polymerase chain reaction (PCR) (ddPCR) is a novel method ...
journal_title:Animal science journal = Nihon chikusan Gakkaihopub_type: 杂志文章
doi:10.1111/asj.13595
更新日期:2021-12-01 00:00:00
abstract::Environmentally, bisphenol A (BPA) is a well-known pollutant caused human health risk, including osteosarcoma (OS). OS, a deadly bone neoplasia, may occur in children and adults. However, the anti-OS pharmacotherapy prescribes limitedly in clinical practice. Interestingly, previous experimental evidences indicate caly...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1956401
更新日期:2021-12-01 00:00:00
abstract::Neisseria gonorrhoeae (gonococcus) causes the human sexually transmitted disease gonorrhea. Studying gonococcal pathogenesis and developing new vaccines and therapies to combat the increasing prevalence of multi-antibiotic resistant bacteria has made use of many ex vivo models based on human cells and tissues, and in ...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1950269
更新日期:2021-12-01 00:00:00
abstract::Myoblasts are myogenic precursors that develop into myotubes during muscle formation. Improving efficiency of myoblast differentiation is important for advancing meat production by domestic animals. We recently identified novel oligodeoxynucleotides (ODNs) termed myogenetic ODNs (myoDNs) that promote the differentiati...
journal_title:Animal science journal = Nihon chikusan Gakkaihopub_type: 杂志文章
doi:10.1111/asj.13597
更新日期:2021-12-01 00:00:00
abstract::Dendrobine has been reported to reduce blood lipid levels and apoptosis. The present study was designed to observe the effect of dendrobine in a model of ERS using vascular endothelial cells and to reveal the biological mechanisms and pathways responsible for the therapeutic effects of dendrobine on AS. Human umbilica...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1956672
更新日期:2021-12-01 00:00:00
abstract::A novel series of thiazole-naphthalene derivatives as tubulin polymerisation inhibitors were designed, synthesised, and evaluated for the anti-proliferative activities. The majority of the tested compounds exhibited moderate to potent antiproliferative activity on the MCF-7 and A549 cancer cell lines. Among them, comp...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1958213
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Conflicting data suggest that statins could cause chronic liver disease in certain group of patients, while improving prognosis in those with chronic viral hepatitis (CVH). PURPOSE:To quantify the potential protective role of statins on some main liver-related health outcomes in clinical studies on CVH pati...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1956686
更新日期:2021-12-01 00:00:00
abstract::Hungatella hathewayi has been observed to be a member of the gut microbiome. Unfortunately, little is known about this organism in spite of being associated with human fatalities; it is important to understand virulence mechanisms and epidemiological prospective to cause disease. In this study, a patient with chronic ...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1950955
更新日期:2021-12-01 00:00:00
abstract::The ageing population is becoming a significant socio-economic issue. To address the expanding health gap, it is important to deepen our understanding of the mechanisms underlying ageing in various organisms at the single-cell level. The discovery of the antifungal, immunosuppressive, and anticancer drug rapamycin, wh...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1955873
更新日期:2021-12-01 00:00:00
abstract::Renal fibrosis (RF) is a pathological process of progression from chronic kidney disease to end-stage renal disease. Amygdalus mongolica is a traditional Chinese medicine, and our previous studies demonstrated that the n-butanol extract (BUT) and amygdalin extract (AMY) from its seeds can prevent RF. However, the unde...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2021.1952212
更新日期:2021-12-01 00:00:00
abstract::To investigate mechanism of pericytes in the early stage of subarachnoid haemorrhage (SAH) and its associated microvascular spasm and neurovascular injury, 100 healthy 8-week-old Sprague-Dawley male rats were taken as subjects and divided into four groups: group A (sham operation, control group), group B (SAH operatio...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1947630
更新日期:2021-12-01 00:00:00
abstract::Intracerebral hemorrhage (ICH) is one of the most common refractory diseases. Long non-coding RNAs (lncRNAs) play crucial roles in ICH. This study was designed to investigate the role of lncRNA H19 in ICH and the underlying molecular mechanisms involved. Real-time quantitative polymerase chain reaction (RT-qPCR) was p...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1951070
更新日期:2021-12-01 00:00:00
abstract::Ovarian cancer (OC) is one of the most common malignancies with high incidence and mortality and the eighth most common cancer-associated mortality in women worldwide. Aberrant expression of the GINS complex subunit 2 (GINS2) gene and miR-502-5p has been associated with cancer progression. This study aims to investiga...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1946347
更新日期:2021-12-01 00:00:00
abstract::The lack of efficient biomarkers is the main reason for the inaccurate early diagnosis and poor treatment outcomes of patients with metabolic syndrome (MetS). The current study aimed to identify several novel microRNA (miRNA) biomarkers for metabolic syndrome via high-throughput sequencing and comprehensive bioinforma...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1952817
更新日期:2021-12-01 00:00:00
abstract::The extracellular matrix (ECM) shows an essential effect during the occurrence and procession of human cancers. Type III collagen is a crucial component of ECM. Collagen Type III Alpha 1(COL3A1) is aberrantly expressed in a variety of cancers. Nevertheless, the role of COL3A1 in pan-cancer stays unidentified. In this ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1949838
更新日期:2021-12-01 00:00:00
abstract::This study aimed to explore the molecular mechanisms related to immune and hub genes related to pulmonary arterial hypertension (PAH). The differentially expressed genes (DEGs) of GSE15197 were identified as filters with adjusted P value <0.05, and |Log2 fold change|> 1. Biofunctional and pathway enrichment annotation...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1944720
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:This study aims to explore the relevance between YKL-40 and recurrence and progression of bladder cancer, and determine whether YKL-40 can be used as a potential target in patients with bladder cancer. METHODS:We analyzed the invasion and metastasis ability of BIU-87, UMUC3, J82, T24, 5637 and immortalized h...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1950920
更新日期:2021-12-01 00:00:00
abstract:PURPOSE:Despite evidence that older persons want to be involved in care, little is known about how frail older people with significant care needs living at home experience participation in care provided by different stakeholders. This study investigates the experiences of participation in care by older people following...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1937896
更新日期:2021-12-01 00:00:00
abstract::Alpha folate receptor (FRα) is currently under investigation as a target for the treatment of patients with non-small-cell lung cancer (NSCLC), since it is highly expressed in tumor cells but is largely absent in normal tissue. In this study, a novel human variable domain of a heavy-chain (VH) antibody fragment specif...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1943055
更新日期:2021-12-01 00:00:00
abstract::The novel coronavirus disease (COVID-19) is one of the worst pandemics in human history. Our research objective is to assess the contagion effect on Japanese firms and to evaluate the Japanese government's COVID-19 measures during the period from April 7, 2020, to May 25, 2020. We propose a susceptible-infected-recove...
journal_title:Research in international business and financepub_type: 杂志文章
doi:10.1016/j.ribaf.2021.101491
更新日期:2021-12-01 00:00:00
abstract::We evaluated the effect of dilution on both the size and packing density of aggregates prepared from a fatty acid (oleic acid, OA)/detergent (3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxypropane sulfonate (CHAPSO)) bicelle as a parent for functional membrane materials. The sizes of the aggregates formed at differen...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19501
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Tripteryguim wilfordii Hook (TWH) has significant anti-inflammatory and immunosuppressive properties and is widely used for treating autoimmune and inflammatory diseases. However, the multi-target mechanism of TWH on ankylosing spondylitis (AS) remains to be elucidated. METHODS:Active components and their t...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1918345
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Streptomyces species are prolific sources of bioactive secondary metabolites known especially for their antimicrobial and anticancer activities. OBJECTIVE:This study sought to isolate and characterize antioxidant molecules biosynthesized by Streptomyces sp. KTM18. The antioxidant potential of an isolated compo...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1946091
更新日期:2021-12-01 00:00:00
abstract::Widespread usage of pesticides in agricultural practice caused their residues to appear in water and food products intended for human consumption. The potential toxicity of these resources has raised awareness about pesticide tracking in the environment. Development of reliable electrochemical sensors for the on-site ...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19541
更新日期:2021-12-01 00:00:00
abstract::In this work, we demonstrate controlled introduction of O-functional groups on commercial carbon nanotube fibers (CNTFs) with different nanotube morphologies obtained by dry- and wet-spinning by treatment with gaseous ozone (O₃(g)). Our test samples were (1) wet-spun fibers of smalldiameter (1-2 nm) singlewall (SW)-CN...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19536
更新日期:2021-12-01 00:00:00
abstract::The ATP-dependent protein DEAD-box RNA helicase 52 (DDX52) is an important regulator in RNA biology and has been implicated in the development of prostate and lung cancer. However, its biological functions and clinical importance in malignant melanoma (MM) are still unclear. Understanding the potential mechanism under...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1950283
更新日期:2021-12-01 00:00:00
abstract::The aim of this study was to estimate the age- and gender-specific prevalence and quality of care among patients using medication targeting obstructive lung disease in the five regions of Greenland. The study was designed as a cross-sectional study. Data on patients using medication targeting obstructive lung disease ...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2021.1948244
更新日期:2021-12-01 00:00:00
abstract::Accumulating evidence has unveiled the pivotal roles of N6-methyladenosine (m6A) in pancreatic adenocarcinoma (PAAD). However, there are not many researches to predict the prognosis of PAAD using m6A-related long non-coding RNAs (lncRNAs). Raw data from The Cancer Genome Atlas (TCGA), International Cancer Genome Conso...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1933868
更新日期:2021-12-01 00:00:00
abstract::Chitosan (CS), the only alkaline polysaccharose available in nature, has always been a promising candidate for drug delivery owing to its excellent biodegradability and biocompatibility. However, inherent solubility and polycationic properties of CS largely hinder electrospinning, which is an efficient method of fabri...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19511
更新日期:2021-12-01 00:00:00
abstract::Micro and nano structures of quartz schist, plagioclase granite, and granitic gneiss in the Xiaomei Shear Zone located in southeastern Hainan Island, China are observed using Scanning Electron Microscope (SEM). Ultramicroscopic analyses indicate that three types of nanoparticles were found in the samples, including sp...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.18887
更新日期:2021-12-01 00:00:00
abstract::The application of electrochemical catalytic oxidation in wastewater treatment with powerful Cldoped graphene as an anode has been discussed as a novel approach to degrade acetaminophen effectively. The characteristics of Cl-doped graphene that were related to Cl loading content and microscopic morphology were analyze...
journal_title:Journal of nanoscience and nanotechnologypub_type: 杂志文章
doi:10.1166/jnn.2021.19526
更新日期:2021-12-01 00:00:00
abstract::Cartilage tissue engineering is a promising option for repairing cartilage defects, although harvesting a large number of seeding cells remains a major challenge. Cartilage stem/progenitor cells (CSPCs) seem to be a promising cell source. Hypoxic extracellular vesicles (EVs) may play a major role in cell-cell and tiss...
journal_title:Adipocytepub_type: 杂志文章
doi:10.1080/21623945.2021.1945210
更新日期:2021-12-01 00:00:00
abstract::Our previous study found that in nasopharyngeal carcinoma (NPC) cells, overexpression of Notch2 can inhibit epithelial-mesenchymal transition (EMT), which plays a vital role in mediating radiosensitivity. The purpose of this study was to explore the radiosensitizing efficacy of the Notch2 gene in NPC cells and its pot...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1949236
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Preeclampsia and hypothyroidism are associated with endothelial dysfunction. Iodine deficiency is a risk factor for subclinical hypothyroidism in pregnancy. However, there is a paucity of data on the relationship between iodine nutrition state in pregnancy, the degree of endothelial dysfunction, and the risk...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1947520
更新日期:2021-12-01 00:00:00
abstract::It is found that the activation of Sonic Hedgehog (SHH) signaling pathway is related to the degree of inflammation in patients suffering from periodontitis. Cullin3 (CUL3), an important ubiquitin ligase, can control SHH signaling. In this study, we were dedicated to clarify the roles of SHH and CUL3 in P. gingivalis-L...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1943603
更新日期:2021-12-01 00:00:00
abstract::Purpose: Intimate care procedures, such as bathing and toileting, are often regarded as simple, humble tasks. However, the provision of such care transforms a very private, personal activity into a social process. Understanding this complex process and the psychological impact it has on those providing and receiving c...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1943123
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:The use of lycopene as a complementary medicine for Type II diabetes mellitus (T2DM) is limited and controversial. This study evaluated the effect of lycopene intake on the changes of glycaemic status and antioxidant capacity among the T2DM patients. PATIENTS AND METHODS:This case-control study involved the...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1943515
更新日期:2021-12-01 00:00:00